Long-term marijuana use changes brain's reward circuit

Marijuana.
Credit score: © laborec425 / Fotolia
Power marijuana use disrupts the mind's pure reward processes, in accordance with researchers on the Heart for BrainHealth at The College of Texas at Dallas.
In a paper revealed in Human Mind Mapping, researchers demonstrated for the primary time with practical magnetic resonance imaging that long-term marijuana customers had extra mind exercise within the mesocorticolimbic-reward system when introduced with hashish cues than with pure reward cues.
"This research reveals that marijuana disrupts the pure reward circuitry of the mind, making marijuana extremely salient to those that use it closely. In essence, these mind alterations may very well be a marker of transition from leisure marijuana use to problematic use," stated Dr. Francesca Filbey, director of Cognitive Neuroscience Analysis in Addictive Issues on the Heart for BrainHealth and affiliate professor within the Faculty of Behavioral and Mind Sciences.
Researchers studied 59 grownup marijuana customers and 70 nonusers, accounting for potential biases equivalent to traumatic mind damage and different drug use. Examine members rated their urge to make use of marijuana after numerous visible hashish cues, equivalent to a pipe, bong, joint or blunt, and self-selected photographs of most well-liked fruit, equivalent to a banana, an apple, grapes or an orange.
Researchers additionally collected self-reports from research members to measure issues related to marijuana use. On common, marijuana members had used the drug for 12 years.
When introduced with marijuana cues in comparison with fruit, marijuana customers confirmed enhanced response within the mind areas related to reward, such because the orbitofrontal cortex, striatum, anterior cingulate gyrus, precuneus and the ventral tegmental space.
"We discovered that this disruption of the reward system correlates with the variety of issues, equivalent to household points, people have due to their marijuana use," Filbey stated. "Continued marijuana use regardless of these issues is an indicator of marijuana dependence."
The analysis was funded by the Nationwide Institute on Drug Abuse.

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